Video from the game showed Nolan Arenado charging the mound after a fastball from Perdomo nearly hit the Rockies batter in the bottom of the third inning.
A wild brawl ensued, with players and coaches from both sides rushing into the field in an attempt to break up the fight.
Nolan Arenado charges the mound after a pitch is thrown behind him. Benches clear in Colorado. pic.twitter.com/vKfMTNU5c1
— FOX Sports San Diego (@FOXSportsSD) April 11, 2018
The brawl likely was instigated by the Tuesday night game when Padres outfielder Manuel Margot was hit in the ribs in the 9th inning.
The Rockies went on to score five runs in the half-inning following the melee, and eventually won 6-4.