Doctors intubate a coronavirus patient in the COVID-19 ICU at Providence Mission Hospital in Mission Viejo. A new study indicates that statin use can help prevent death in hospitalized COVID patients. REUTERS/Lucy Nicholson

A study published Thursday by the UC San Diego School of Medicine found that patients taking statin medications had a 41% lower risk of in-hospital death from COVID-19.

The findings were published Thursday in the peer-reviewed journal PLOS ONE and expand upon research conducted at UCSD Health in 2020.

Statins are commonly used to reduce blood cholesterol levels by blocking liver enzymes responsible for making cholesterol. They are widely prescribed: The U.S. Centers for Disease Control estimates that 93% of patients who use a cholesterol-lowering drug use a statin.

“When faced with this virus at the beginning of the pandemic, there was a lot of speculation surrounding certain medications that affect the body’s ACE2 receptor, including statins, and whether they may influence COVID-19 risk,” said Dr. Lori Daniels, professor and director of the Cardiovascular Intensive Care Unit at UCSD Health.

“At the time, we thought that statins may inhibit SARS-CoV-2 infection through their known anti-inflammatory effects and binding capabilities, which could potentially stop progression of the virus,” she continued.

The ACE2 receptor – the regulatory target of statins – helps control blood pressure. In 2020, it was discovered that SARS-CoV-2 virus primarily uses the same receptor to enter lung cells.

Using data from the American Heart Association’s COVID-19 Cardiovascular Disease Registry, the research team at UCSD applied their findings to a much larger cohort across the U.S.

Specifically, researchers analyzed anonymized medical records of 10,541 patients admitted at 104 different hospitals for treatment of COVID-19 over a nine-month period through September 2020.

“From this data, we performed more advanced analyses as we attempted to control for coexisting medical conditions, socioeconomic status and hospital factors,” Daniels said. “In doing so, we confirmed our prior findings that statins are associated with a reduced risk of death from COVID-19 among patients hospitalized for COVID-19.”

Daniels said it appears most of the benefit is among patients with good medical reasons to be taking statins, such as a history of cardiovascular disease or high blood pressure.

According to the research team, the use of statins or an anti-hypertension medication was associated with a 32% lower risk of death among COVID-19 inpatients with a history of cardiovascular disease or high blood pressure.

In the study, statistical matching techniques were used to compare outcomes for patients who used statins or anti-hypertension medications against similar patients who did not.

“We matched each patient to one or more similar patients, using hospital site, month of admission, age, race, ethnicity, gender and a list of pre-existing conditions, in order to make the two groups as comparable as possible,” said Karen Messer, study co-author and professor of biostatistics at UCSD’s School of Medicine.

According to researchers, statins and anti-hypertension medications stabilize the underlying diseases for which they are prescribed, making patients more likely to recover from COVID-19.

“As with any observational study, we cannot say for certain that the associations we describe between statin use and reduced severity of COVID-19 infection are definitely due to the statins themselves; however, we can now say with very strong evidence that they may play a role in substantially lowering a patient’s risk of death from COVID-19,” said Daniels.

“We hope that our research findings are an incentive for patients to continue with their medication,” she concluded.

The initial study included 170 anonymized medical records from patients receiving care at UCSD Health. Researchers found that statin use prior to hospital admission for COVID-19 resulted in a more than 50% reduction in the risk of developing severe infection.

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