Caltrans will close eastbound State Route 52 between Interstate 805 and State Route 163 from Saturday night until Monday morning to repair pavement dips.
The work will begin at 7 p.m. Saturday night and continue until 5 a.m. Monday morning.
All eastbound lanes will be closed, as well as the connector ramps from northbound and southbound Route 163 and the Convoy Street on-ramp to eastbound Route 52.
Drivers will be detoured south on Interstate 805 to Interstate 8 and then north on Interstate 15.
Caltrans said message signs are already alerting drivers to the upcoming closure.
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